BDBM16937 5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}-3-(propan-2-ylidene)-2,3-dihydro-1H-indol-2-one::oxindole pyridine, 9s

SMILES: CC(C)=C1C(=O)Nc2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1

InChI Key: InChIKey=YAAYJTOFCDAUQL-FQEVSTJZSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16937   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM16937 (5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...) Show SMILES CC(C)=C1C(=O)Nc2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1 |r,wU:20.22,(-12.05,2.37,;-10.54,2.69,;-9.45,1.6,;-10.07,4.16,;-10.97,5.4,;-12.51,5.4,;-10.07,6.65,;-8.6,6.17,;-7.27,6.94,;-5.93,6.17,;-5.93,4.63,;-7.27,3.86,;-8.6,4.63,;-4.6,3.86,;-4.6,2.32,;-3.27,1.55,;-1.93,2.32,;-1.93,3.86,;-.6,4.63,;.73,3.86,;2.07,4.63,;2.07,6.17,;3.4,3.86,;4.74,4.63,;4.28,6.1,;5.53,6.99,;6.77,6.07,;8.28,6.37,;9.3,5.22,;8.8,3.76,;7.29,3.46,;6.28,4.61,;-3.27,4.63,)| Show InChI InChI=1S/C27H26N4O2/c1-16(2)26-23-11-17(7-8-25(23)31-27(26)32)18-10-21(14-29-12-18)33-15-20(28)9-19-13-30-24-6-4-3-5-22(19)24/h3-8,10-14,20,30H,9,15,28H2,1-2H3,(H,31,32)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of Akt				Eur J Med Chem 44: 4090-7 (2009) Article DOI: 10.1016/j.ejmech.2009.04.050 BindingDB Entry DOI: 10.7270/Q2GT5N74
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase [139-480,S378A,S381A,T450D,S473D] (Homo sapiens (Human))	BDBM16937 (5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...) Show SMILES CC(C)=C1C(=O)Nc2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1 |r,wU:20.22,(-12.05,2.37,;-10.54,2.69,;-9.45,1.6,;-10.07,4.16,;-10.97,5.4,;-12.51,5.4,;-10.07,6.65,;-8.6,6.17,;-7.27,6.94,;-5.93,6.17,;-5.93,4.63,;-7.27,3.86,;-8.6,4.63,;-4.6,3.86,;-4.6,2.32,;-3.27,1.55,;-1.93,2.32,;-1.93,3.86,;-.6,4.63,;.73,3.86,;2.07,4.63,;2.07,6.17,;3.4,3.86,;4.74,4.63,;4.28,6.1,;5.53,6.99,;6.77,6.07,;8.28,6.37,;9.3,5.22,;8.8,3.76,;7.29,3.46,;6.28,4.61,;-3.27,4.63,)| Show InChI InChI=1S/C27H26N4O2/c1-16(2)26-23-11-17(7-8-25(23)31-27(26)32)18-10-21(14-29-12-18)33-15-20(28)9-19-13-30-24-6-4-3-5-22(19)24/h3-8,10-14,20,30H,9,15,28H2,1-2H3,(H,31,32)/t20-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52.7	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 3424-9 (2006) Article DOI: 10.1016/j.bmcl.2006.04.005 BindingDB Entry DOI: 10.7270/Q2K072JJ
					More data for this Ligand-Target Pair