BDBM17048 Indolinone based inhibitor, 4j::[(3Z)-2-oxo-3-[1-(1H-pyrrol-2-yl)propylidene]-2,3-dihydro-1H-indol-5-yl]urea

SMILES: CC\C(=C1\C(=O)Nc2ccc(NC(N)=O)cc12)c1ccc[nH]1

InChI Key: InChIKey=ONFAWAGNIRCQMX-UVTDQMKNSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17048   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-phosphoinositide dependent protein kinase-1 (Homo sapiens (Human))	BDBM17048 (Indolinone based inhibitor, 4j | [(3Z)-2-oxo-3-[1-...) Show SMILES CC\C(=C1\C(=O)Nc2ccc(NC(N)=O)cc12)c1ccc[nH]1 Show InChI InChI=1S/C16H16N4O2/c1-2-10(12-4-3-7-18-12)14-11-8-9(19-16(17)22)5-6-13(11)20-15(14)21/h3-8,18H,2H2,1H3,(H,20,21)(H3,17,19,22)/b14-10-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3814-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.071 BindingDB Entry DOI: 10.7270/Q25Q4TBB
					More data for this Ligand-Target Pair