BDBM17057 7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-1,2,3,4-tetrahydroquinazolin-2-one::Dihydro-quinazolinone analog, 6

SMILES: Nc1cc2N(C(=O)NCc2c(c1)-c1ccccc1Cl)c1c(Cl)cccc1Cl

InChI Key: InChIKey=WIQAOFODRZQKAO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17057   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase p38 (Mus musculus (mouse))	BDBM17057 (7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-...) Show SMILES Nc1cc2N(C(=O)NCc2c(c1)-c1ccccc1Cl)c1c(Cl)cccc1Cl Show InChI InChI=1S/C20H14Cl3N3O/c21-15-5-2-1-4-12(15)13-8-11(24)9-18-14(13)10-25-20(27)26(18)19-16(22)6-3-7-17(19)23/h1-9H,10,24H2,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.0	30
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 4400-4 (2006) Article DOI: 10.1016/j.bmcl.2006.05.045 BindingDB Entry DOI: 10.7270/Q2NS0S56
					More data for this Ligand-Target Pair