BDBM17063 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-methanesulfonyl-1H,2H,3H,4H-[1,3]diazino[4,5-d]pyrimidin-2-one::pyrimido-pyrimidine, 20

SMILES: CS(=O)(=O)c1nc2N(C(=O)NCc2c(n1)-c1ccccc1Cl)c1c(Cl)cccc1Cl

InChI Key: InChIKey=LDJYQPLHXNCUPI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17063   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase p38 (Mus musculus (mouse))	BDBM17063 (5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-methan...) Show SMILES CS(=O)(=O)c1nc2N(C(=O)NCc2c(n1)-c1ccccc1Cl)c1c(Cl)cccc1Cl Show InChI InChI=1S/C19H13Cl3N4O3S/c1-30(28,29)18-24-15(10-5-2-3-6-12(10)20)11-9-23-19(27)26(17(11)25-18)16-13(21)7-4-8-14(16)22/h2-8H,9H2,1H3,(H,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	7.0	30
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 4400-4 (2006) Article DOI: 10.1016/j.bmcl.2006.05.045 BindingDB Entry DOI: 10.7270/Q2NS0S56
					More data for this Ligand-Target Pair