BDBM17064 7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-1H,2H,3H,4H-[1,3]diazino[4,5-d]pyrimidin-2-one::pyrimido-pyrimidine, 24

SMILES: Nc1nc2N(C(=O)NCc2c(n1)-c1ccccc1Cl)c1c(Cl)cccc1Cl

InChI Key: InChIKey=PQASAXDWZSDGOL-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17064   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase p38 (Mus musculus (mouse))	BDBM17064 (7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-...) Show SMILES Nc1nc2N(C(=O)NCc2c(n1)-c1ccccc1Cl)c1c(Cl)cccc1Cl Show InChI InChI=1S/C18H12Cl3N5O/c19-11-5-2-1-4-9(11)14-10-8-23-18(27)26(16(10)25-17(22)24-14)15-12(20)6-3-7-13(15)21/h1-7H,8H2,(H,23,27)(H2,22,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30	n/a	n/a	n/a	n/a	7.0	30
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 4400-4 (2006) Article DOI: 10.1016/j.bmcl.2006.05.045 BindingDB Entry DOI: 10.7270/Q2NS0S56
					More data for this Ligand-Target Pair