BDBM17069 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-{1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl}-1H,2H,3H,4H-[1,3]diazino[4,5-d]pyrimidin-2-one::pyrimido-pyrimidine, 29

SMILES: Clc1ccccc1-c1nc(nc2N(C(=O)NCc12)c1c(Cl)cccc1Cl)N1CCc2[nH]ncc2C1

InChI Key: InChIKey=NRJVTEDJTWVQDN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17069   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase p38 (Mus musculus (mouse))	BDBM17069 (5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-{1H,4H...) Show SMILES Clc1ccccc1-c1nc(nc2N(C(=O)NCc12)c1c(Cl)cccc1Cl)N1CCc2[nH]ncc2C1 Show InChI InChI=1S/C24H18Cl3N7O/c25-16-5-2-1-4-14(16)20-15-11-28-24(35)34(21-17(26)6-3-7-18(21)27)22(15)31-23(30-20)33-9-8-19-13(12-33)10-29-32-19/h1-7,10H,8-9,11-12H2,(H,28,35)(H,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.0	30
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 4400-4 (2006) Article DOI: 10.1016/j.bmcl.2006.05.045 BindingDB Entry DOI: 10.7270/Q2NS0S56
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