BDBM17076 5-(2,4-dichlorophenyl)-1-(2,6-dichlorophenyl)-7-[4-(propan-2-yl)piperazin-1-yl]-1H,2H,3H,4H-[1,3]diazino[4,5-d]pyrimidin-2-one::pyrimido-pyrimidine, 36

SMILES: CC(C)N1CCN(CC1)c1nc2N(C(=O)NCc2c(n1)-c1ccc(Cl)cc1Cl)c1c(Cl)cccc1Cl

InChI Key: InChIKey=XOKLRIBOHSHHOV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17076   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase p38 (Mus musculus (mouse))	BDBM17076 (5-(2,4-dichlorophenyl)-1-(2,6-dichlorophenyl)-7-[4...) Show SMILES CC(C)N1CCN(CC1)c1nc2N(C(=O)NCc2c(n1)-c1ccc(Cl)cc1Cl)c1c(Cl)cccc1Cl Show InChI InChI=1S/C25H24Cl4N6O/c1-14(2)33-8-10-34(11-9-33)24-31-21(16-7-6-15(26)12-20(16)29)17-13-30-25(36)35(23(17)32-24)22-18(27)4-3-5-19(22)28/h3-7,12,14H,8-11,13H2,1-2H3,(H,30,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.0	30
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 4400-4 (2006) Article DOI: 10.1016/j.bmcl.2006.05.045 BindingDB Entry DOI: 10.7270/Q2NS0S56
					More data for this Ligand-Target Pair