BDBM171315 US9085555, 745

SMILES: Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@]4(C)C[C@H]3C(=O)Nc3cccc(Br)n3)c2cn1)C(N)=O

InChI Key: InChIKey=RQSGAFKFWASFPG-IEROGBPDSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 171315   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM171315 (US9085555, 745) Show SMILES Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@]4(C)C[C@H]3C(=O)Nc3cccc(Br)n3)c2cn1)C(N)=O |r| Show InChI InChI=1S/C22H22BrN7O3/c1-11-6-12-14(9-25-11)29(28-19(12)20(24)32)10-18(31)30-13(7-22(2)8-15(22)30)21(33)27-17-5-3-4-16(23)26-17/h3-6,9,13,15H,7-8,10H2,1-2H3,(H2,24,32)(H,26,27,33)/t13-,15+,22-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.5	25
NOVARTIS AG US Patent					Assay Description Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...				US Patent US9085555 (2015) BindingDB Entry DOI: 10.7270/Q2RN36MP
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