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SMILES: CN(Cc1ccc(cc1)C(=O)Nc1cc(ccc1O)-c1ccccc1)c1ccncc1

InChI Key: InChIKey=ZLOHMUBFEMBXKD-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 172863   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 1


(Homo sapiens (Human))		BDBM172863
PNG
(US9096559, 103)
Show SMILES CN(Cc1ccc(cc1)C(=O)Nc1cc(ccc1O)-c1ccccc1)c1ccncc1
Show InChI InChI=1S/C26H23N3O2/c1-29(23-13-15-27-16-14-23)18-19-7-9-21(10-8-19)26(31)28-24-17-22(11-12-25(24)30)20-5-3-2-4-6-20/h2-17,30H,18H2,1H3,(H,28,31)
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Similars
US Patent
n/an/a 13n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Novel compounds were tested for their ability to inhibit histone deacetylase, subtype 1 (HDAC1) using an in vitro deacetylation assay. The enzyme sou...

US Patent US9096559 (2015)


BindingDB Entry DOI: 10.7270/Q2K07317
More data for this
Ligand-Target Pair