null

SMILES: COC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(Cl)c2[nH]1

InChI Key: InChIKey=NAYCPOVQYKXRMT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 172997   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM172997 (US9096579, 99) Show SMILES COC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(Cl)c2[nH]1 Show InChI InChI=1S/C18H15ClN6O2/c1-25-8-15(21-9-25)13-3-4-20-18(24-13)22-11-5-10-6-14(17(26)27-2)23-16(10)12(19)7-11/h3-9,23H,1-2H3,(H,20,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15.7	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US9096579 (2015) BindingDB Entry DOI: 10.7270/Q2F76B9H
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM172997 (US9096579, 99) Show SMILES COC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(Cl)c2[nH]1 Show InChI InChI=1S/C18H15ClN6O2/c1-25-8-15(21-9-25)13-3-4-20-18(24-13)22-11-5-10-6-14(17(26)27-2)23-16(10)12(19)7-11/h3-9,23H,1-2H3,(H,20,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US9096579 (2015) BindingDB Entry DOI: 10.7270/Q2F76B9H
					More data for this Ligand-Target Pair