BDBM173071 US9096579, 173

SMILES: Cc1nnc(o1)-c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1

InChI Key: InChIKey=UTOXRAOHVJYMRN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 173071   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM173071 (US9096579, 173) Show SMILES Cc1nnc(o1)-c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1 Show InChI InChI=1S/C20H18N8O/c1-11-6-14(7-13-8-16(24-18(11)13)19-27-26-12(2)29-19)23-20-21-5-4-15(25-20)17-9-28(3)10-22-17/h4-10,24H,1-3H3,(H,21,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US9096579 (2015) BindingDB Entry DOI: 10.7270/Q2F76B9H
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM173071 (US9096579, 173) Show SMILES Cc1nnc(o1)-c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1 Show InChI InChI=1S/C20H18N8O/c1-11-6-14(7-13-8-16(24-18(11)13)19-27-26-12(2)29-19)23-20-21-5-4-15(25-20)17-9-28(3)10-22-17/h4-10,24H,1-3H3,(H,21,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US9096579 (2015) BindingDB Entry DOI: 10.7270/Q2F76B9H
					More data for this Ligand-Target Pair