BDBM173098 US9096589, 5,7-Dimethyl-2-{2-[1-(2-morpholin-4-yl-ethyl)-4-thiophen-2-yl-1H-imidazol-2-yl]-ethyl}-imidazo[1,2-a]pyrimidine::US9669029, 19 5,7-Dimethyl-2-{2-[1-(2-morpholin-4-yl-ethyl)-4-thiophen-2-yl-1H-imidazol-2-yl]-ethyl}-imidazo[1,2-a]pyrimidine

SMILES: Cc1cc(C)n2cc(CCc3nc(cn3CCN3CCOCC3)-c3cccs3)nc2n1

InChI Key: InChIKey=CTLWTUUJCCKOQB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 173098   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM173098 (US9096589, 5,7-Dimethyl-2-{2-[1-(2-morpholin-4-yl-...) Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3CCN3CCOCC3)-c3cccs3)nc2n1 Show InChI InChI=1S/C23H28N6OS/c1-17-14-18(2)29-15-19(25-23(29)24-17)5-6-22-26-20(21-4-3-13-31-21)16-28(22)8-7-27-9-11-30-12-10-27/h3-4,13-16H,5-12H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM173098 (US9096589, 5,7-Dimethyl-2-{2-[1-(2-morpholin-4-yl-...) Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3CCN3CCOCC3)-c3cccs3)nc2n1 Show InChI InChI=1S/C23H28N6OS/c1-17-14-18(2)29-15-19(25-23(29)24-17)5-6-22-26-20(21-4-3-13-31-21)16-28(22)8-7-27-9-11-30-12-10-27/h3-4,13-16H,5-12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9096589 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TTM
					More data for this Ligand-Target Pair