BDBM173101 US9096589, 1-{2-[2-(5,7-Dimethyl-imidazo[1,2-a]pyrimidin-2-yl)-ethyl]-4-thiophen-2-yl-imidazol-1-yl}-3-methoxy-propan-2-ol

SMILES: COCC(O)Cn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1

InChI Key: InChIKey=BQTCNLJBJDNHJW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 173101   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM173101 (US9096589, 1-{2-[2-(5,7-Dimethyl-imidazo[1,2-a]pyr...) Show SMILES COCC(O)Cn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1 Show InChI InChI=1S/C21H25N5O2S/c1-14-9-15(2)26-10-16(23-21(26)22-14)6-7-20-24-18(19-5-4-8-29-19)12-25(20)11-17(27)13-28-3/h4-5,8-10,12,17,27H,6-7,11,13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9096589 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TTM
					More data for this Ligand-Target Pair