BDBM173103 US9096589, 2-[2-(1-Isopropyl-4-thiophen-2-yl-1H-imidazol-2-yl)-ethyl]-5,7-dimethyl-imidazo[1,2-a]pyrimidine::US9669029, 24 2-[2-(1-Isopropyl-4-thiophen-2-yl-1H-imidazol-2-yl)-ethyl]-5,7-dimethyl-imidazo[1,2-a]pyrimidine
SMILES: CC(C)n1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1
InChI Key: InChIKey=FZXKTJYIBVRUJN-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human)) | BDBM173103 (US9096589, 2-[2-(1-Isopropyl-4-thiophen-2-yl-1H-im...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | 25 |
TBA US Patent | Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s... | US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM173103 (US9096589, 2-[2-(1-Isopropyl-4-thiophen-2-yl-1H-im...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | 25 |
H. Lundbeck A/S US Patent | Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme... | US Patent US9096589 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TTM | |||||||||||
More data for this Ligand-Target Pair |