BDBM173105 US9096589, 5,7-Dimethyl-2-{2-[1-(3-methyl-butyl)-4-thiophen-2-yl-1H-imidazol-2-yl]-ethyl}-imidazo[1,2-a]pyrimidine::US9669029, 26 5,7-Dimethyl-2-{2-[1-(3-methyl-butyl)-4-thiophen-2-yl-1H-imidazol-2-yl]-ethyl}-imidazo[1,2-a]pyrimidine

SMILES: CC(C)CCn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1

InChI Key: InChIKey=YAACRQBYHXRYJU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 173105   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM173105 (US9096589, 5,7-Dimethyl-2-{2-[1-(3-methyl-butyl)-4...) Show SMILES CC(C)CCn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1 Show InChI InChI=1S/C22H27N5S/c1-15(2)9-10-26-14-19(20-6-5-11-28-20)25-21(26)8-7-18-13-27-17(4)12-16(3)23-22(27)24-18/h5-6,11-15H,7-10H2,1-4H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM173105 (US9096589, 5,7-Dimethyl-2-{2-[1-(3-methyl-butyl)-4...) Show SMILES CC(C)CCn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1 Show InChI InChI=1S/C22H27N5S/c1-15(2)9-10-26-14-19(20-6-5-11-28-20)25-21(26)8-7-18-13-27-17(4)12-16(3)23-22(27)24-18/h5-6,11-15H,7-10H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9096589 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TTM
					More data for this Ligand-Target Pair