BDBM173114 US9096589, (S)-2-{2-[2-(5-Methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-ethyl]-4-thiophen-2-yl-imidazol-1-yl}-propan-1-ol
SMILES: C[C@@H](CO)n1cc(nc1CCc1nc2cccc(C)n2n1)-c1cccs1
InChI Key: InChIKey=OLDIOLRFUNEQQG-AWEZNQCLSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM173114 (US9096589, (S)-2-{2-[2-(5-Methyl-[1,2,4]triazolo[1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | 25 |
H. Lundbeck A/S US Patent | Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme... | US Patent US9096589 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TTM | |||||||||||
More data for this Ligand-Target Pair |