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SMILES: Cc1ccc(o1)-c1cn(C)c(CCc2nc3c(F)cccn3n2)n1

InChI Key: InChIKey=QGYPQSXAESDJEJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 173142   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM173142
PNG
(US9096589, 8-Fluoro-2-{2-[1-methyl-4-(5-methyl-fur...)
Show SMILES Cc1ccc(o1)-c1cn(C)c(CCc2nc3c(F)cccn3n2)n1
Show InChI InChI=1S/C17H16FN5O/c1-11-5-6-14(24-11)13-10-22(2)16(19-13)8-7-15-20-17-12(18)4-3-9-23(17)21-15/h3-6,9-10H,7-8H2,1-2H3
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US Patent
n/an/a 94n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...

US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair