BDBM173174 US9096589, 4-{2-[2-(8-Methoxy-5-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-ethyl]-4-thiophen-2-yl-imidazol-1-yl}-butyronitrile

SMILES: COc1ccc(C)n2nc(CCc3nc(cn3CCCC#N)-c3cccs3)nc12

InChI Key: InChIKey=WTNIWJOIJQYMCT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 173174   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM173174 (US9096589, 4-{2-[2-(8-Methoxy-5-methyl-[1,2,4]tria...) Show SMILES COc1ccc(C)n2nc(CCc3nc(cn3CCCC#N)-c3cccs3)nc12 Show InChI InChI=1S/C21H22N6OS/c1-15-7-8-17(28-2)21-24-19(25-27(15)21)9-10-20-23-16(18-6-5-13-29-18)14-26(20)12-4-3-11-22/h5-8,13-14H,3-4,9-10,12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9096589 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TTM
					More data for this Ligand-Target Pair