BDBM17329 1-(2-{[(4-cyanophenyl)methyl][(1-methyl-1H-imidazol-5-yl)methyl]amino}acetyl)-5-(naphthalen-1-yl)-1,2,3,6-tetrahydropyridine-4-carbonitrile::N,N-disubstituted glycine derivative, 25

SMILES: Cn1cncc1CN(CC(=O)N1CCC(C#N)=C(C1)c1cccc2ccccc12)Cc1ccc(cc1)C#N

InChI Key: InChIKey=HPWFMVCDEHCXQQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17329   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM17329 (1-(2-{[(4-cyanophenyl)methyl][(1-methyl-1H-imidazo...) Show SMILES Cn1cncc1CN(CC(=O)N1CCC(C#N)=C(C1)c1cccc2ccccc12)Cc1ccc(cc1)C#N |c:17| Show InChI InChI=1S/C31H28N6O/c1-35-22-34-17-27(35)19-36(18-24-11-9-23(15-32)10-12-24)21-31(38)37-14-13-26(16-33)30(20-37)29-8-4-6-25-5-2-3-7-28(25)29/h2-12,17,22H,13-14,18-21H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 13: 1359-62 (2003) Article DOI: 10.1016/S0960-894X(03)00095-7 BindingDB Entry DOI: 10.7270/Q2QJ7FK9
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