BDBM17331 1-[(2R)-3-(4-cyanophenyl)-2-{[(1-methyl-1H-imidazol-5-yl)methyl]amino}propanoyl]-5-(naphthalen-1-yl)-1,2,3,6-tetrahydropyridine-4-carbonitrile::cyanophenylalanine derivative, 29

SMILES: Cn1cncc1CN[C@H](Cc1ccc(cc1)C#N)C(=O)N1CCC(C#N)=C(C1)c1cccc2ccccc12

InChI Key: InChIKey=BJWQPVDYERJHJK-SSEXGKCCSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17331   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM17331 (1-[(2R)-3-(4-cyanophenyl)-2-{[(1-methyl-1H-imidazo...) Show SMILES Cn1cncc1CN[C@H](Cc1ccc(cc1)C#N)C(=O)N1CCC(C#N)=C(C1)c1cccc2ccccc12 |r,c:27| Show InChI InChI=1S/C31H28N6O/c1-36-21-34-18-26(36)19-35-30(15-22-9-11-23(16-32)12-10-22)31(38)37-14-13-25(17-33)29(20-37)28-8-4-6-24-5-2-3-7-27(24)28/h2-12,18,21,30,35H,13-15,19-20H2,1H3/t30-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 13: 1359-62 (2003) Article DOI: 10.1016/S0960-894X(03)00095-7 BindingDB Entry DOI: 10.7270/Q2QJ7FK9
					More data for this Ligand-Target Pair