BDBM1734 2-Amino-6-arylthiobenzonitrile deriv. 1d::2-amino-6-[(4-methoxyphenyl)sulfanyl]benzonitrile

SMILES: COc1ccc(Sc2cccc(N)c2C#N)cc1

InChI Key: InChIKey=YQJXGFCLYVGNMC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 1734   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM1734 (2-Amino-6-arylthiobenzonitrile deriv. 1d | 2-amino...) Show SMILES COc1ccc(Sc2cccc(N)c2C#N)cc1 Show InChI InChI=1S/C14H12N2OS/c1-17-10-5-7-11(8-6-10)18-14-4-2-3-13(16)12(14)9-15/h2-8H,16H2,1H3	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.70E+4	n/a	n/a	n/a	n/a	8.0	n/a
GlaxoSmithKline					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 44: 1866-82 (2001) Article DOI: 10.1021/jm0004906 BindingDB Entry DOI: 10.7270/Q2FJ2F09
					More data for this Ligand-Target Pair