BDBM173681 US9102591, 3-bromo-N-((4,4-difluoro-1-(6-(trifluoromethyl)pyridin-3-yl)cyclohexyl)methyl)-2-methylbenzamide::US9649308, 3-bromo-N-((4,4-difluoro-1-(6-(trifluoromethyl)pyridin-3-yl)cyclohexyl)methyl)-2-methylbenzamide
SMILES: Cc1c(Br)cccc1C(=O)NCC1(CCC(F)(F)CC1)c1ccc(nc1)C(F)(F)F
InChI Key: InChIKey=RIFLDBVPRODDEU-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM173681 (US9102591, 3-bromo-N-((4,4-difluoro-1-(6-(trifluor...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S US Patent | Assay Description Fluorescent Imaging Plate Reader (FLIPR) assay: Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), N... | US Patent US9649308 (2017) BindingDB Entry DOI: 10.7270/Q2BG2R29 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM173681 (US9102591, 3-bromo-N-((4,4-difluoro-1-(6-(trifluor...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | 7.4 | 25 |
H. Lundbeck A/S US Patent | Assay Description Fluorescent Imaging Plate Reader (FLIPR) assay: Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), N... | US Patent US9102591 (2015) BindingDB Entry DOI: 10.7270/Q2028Q92 | |||||||||||
More data for this Ligand-Target Pair |