null

SMILES: CCc1ccc(Cl)cc1-n1cc(cc1C#N)-c1cc(N)ncn1

InChI Key: InChIKey=HBJIIDHYVKJEPX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 173934   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM173934 (US9688661, 4-(6-aminopyrimidin-4-yl)-1-(5-chloro-2...) Show SMILES CCc1ccc(Cl)cc1-n1cc(cc1C#N)-c1cc(N)ncn1 Show InChI InChI=1S/C17H14ClN5/c1-2-11-3-4-13(18)6-16(11)23-9-12(5-14(23)8-19)15-7-17(20)22-10-21-15/h3-7,9-10H,2H2,1H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...				US Patent US9688661 (2017) BindingDB Entry DOI: 10.7270/Q2K35RTP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [861-1152] (Homo sapiens (Human))	BDBM173934 (US9688661, 4-(6-aminopyrimidin-4-yl)-1-(5-chloro-2...) Show SMILES CCc1ccc(Cl)cc1-n1cc(cc1C#N)-c1cc(N)ncn1 Show InChI InChI=1S/C17H14ClN5/c1-2-11-3-4-13(18)6-16(11)23-9-12(5-14(23)8-19)15-7-17(20)22-10-21-15/h3-7,9-10H,2H2,1H3,(H2,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	869	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...				US Patent US9688661 (2017) BindingDB Entry DOI: 10.7270/Q2K35RTP
					More data for this Ligand-Target Pair