BDBM174557 US9688676, 22 (S)-1-((1-acryloylpyrrolidin-2-yl)methyl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one

SMILES: C\C=C/N1CCCC1Cn1c2ccnc(N)c2n(-c2ccc(Oc3cccc(F)c3F)cc2)c1=O

InChI Key: InChIKey=MAGNVVZQKDWGKK-VVHNFQOZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 174557   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM174557 (US9688676, 22 (S)-1-((1-acryloylpyrrolidin-2-yl)me...) Show SMILES C\C=C/N1CCCC1Cn1c2ccnc(N)c2n(-c2ccc(Oc3cccc(F)c3F)cc2)c1=O Show InChI InChI=1S/C26H25F2N5O2/c1-2-14-31-15-4-5-18(31)16-32-21-12-13-30-25(29)24(21)33(26(32)34)17-8-10-19(11-9-17)35-22-7-3-6-20(27)23(22)28/h2-3,6-14,18H,4-5,15-16H2,1H3,(H2,29,30)/b14-2-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	25
PRINCIPIA BIOPHARMA INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of BTK kinase activity of a compound of the pre...				US Patent US9688676 (2017) BindingDB Entry DOI: 10.7270/Q2XD0ZVX
					More data for this Ligand-Target Pair