BDBM174781 US10053462, 12::US9102686, 12::US9540388, 12
SMILES: Fc1ccc(nc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
InChI Key: InChIKey=KAXAHUBBXCYPAA-WBMJQRKESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P2X purinoceptor 7 (Mus musculus) | BDBM174781 (US10053462, 12 | US9102686, 12 | US9540388, 12) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according... | US Patent US10053462 (2018) BindingDB Entry DOI: 10.7270/Q2KK9DSF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM174781 (US10053462, 12 | US9102686, 12 | US9540388, 12) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.40 | n/a | 13 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose... | US Patent US9540388 (2017) BindingDB Entry DOI: 10.7270/Q20V8B0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat)) | BDBM174781 (US10053462, 12 | US9102686, 12 | US9540388, 12) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.40 | n/a | 1.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ... | US Patent US9540388 (2017) BindingDB Entry DOI: 10.7270/Q20V8B0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat)) | BDBM174781 (US10053462, 12 | US9102686, 12 | US9540388, 12) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.40 | n/a | 37 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose... | US Patent US9540388 (2017) BindingDB Entry DOI: 10.7270/Q20V8B0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat)) | BDBM174781 (US10053462, 12 | US9102686, 12 | US9540388, 12) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according... | US Patent US9102686 (2015) BindingDB Entry DOI: 10.7270/Q22V2DXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM174781 (US10053462, 12 | US9102686, 12 | US9540388, 12) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 12.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according... | US Patent US10053462 (2018) BindingDB Entry DOI: 10.7270/Q2KK9DSF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM174781 (US10053462, 12 | US9102686, 12 | US9540388, 12) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 12.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according... | US Patent US9102686 (2015) BindingDB Entry DOI: 10.7270/Q22V2DXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM174781 (US10053462, 12 | US9102686, 12 | US9540388, 12) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 13 | n/a | 1.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ... | US Patent US9540388 (2017) BindingDB Entry DOI: 10.7270/Q20V8B0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM174781 (US10053462, 12 | US9102686, 12 | US9540388, 12) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 13.3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose... | US Patent US10053462 (2018) BindingDB Entry DOI: 10.7270/Q2KK9DSF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat)) | BDBM174781 (US10053462, 12 | US9102686, 12 | US9540388, 12) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 36.6 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description Ca.sup.2+flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Me... | US Patent US9102686 (2015) BindingDB Entry DOI: 10.7270/Q22V2DXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM174781 (US10053462, 12 | US9102686, 12 | US9540388, 12) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 13.3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description Ca.sup.2+flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Me... | US Patent US9102686 (2015) BindingDB Entry DOI: 10.7270/Q22V2DXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Mus musculus) | BDBM174781 (US10053462, 12 | US9102686, 12 | US9540388, 12) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 36.6 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose... | US Patent US10053462 (2018) BindingDB Entry DOI: 10.7270/Q2KK9DSF | |||||||||||
More data for this Ligand-Target Pair |