BDBM175322 (E)-N'-(3-bromo-4-hydroxybenzylidene)-4-(5,6-dimethyl-1H-benzo[d] imidazol-2-yl)benzohydrazide (17)

SMILES: Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1ccc(O)c(Br)c1

InChI Key: InChIKey=KUIYPDJNXSESAN-BRJLIKDPSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 175322   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
α-glucosidase (Saccharomyces cerevisiae S288c (Baker's yeast))	BDBM175322 ((E)-N'-(3-bromo-4-hydroxybenzylidene)-4-(5,6-d...) Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1ccc(O)c(Br)c1 Show InChI InChI=1S/C23H19BrN4O2/c1-13-9-19-20(10-14(13)2)27-22(26-19)16-4-6-17(7-5-16)23(30)28-25-12-15-3-8-21(29)18(24)11-15/h3-12,29H,1-2H3,(H,26,27)(H,28,30)/b25-12+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.45E+4	n/a	n/a	n/a	n/a	6.8	n/a
Universiti Teknologi MARA (UiTM)					Assay Description The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...				Bioorg Chem 64: 29-36 (2016) Article DOI: 10.1016/j.bioorg.2015.11.006 BindingDB Entry DOI: 10.7270/Q2W37V2M
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