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BDBM175793 US9688683, 51

SMILES: CCc1nc(nc2N(CCc12)c1cccc(OC(=O)NCC2CC2)c1)-c1ccc(OC)c(F)c1

InChI Key: InChIKey=LLDDKNBBWYQJCY-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 175793   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM175793
PNG
(US9688683, 51)
Show SMILES CCc1nc(nc2N(CCc12)c1cccc(OC(=O)NCC2CC2)c1)-c1ccc(OC)c(F)c1
Show InChI InChI=1S/C26H27FN4O3/c1-3-22-20-11-12-31(18-5-4-6-19(14-18)34-26(32)28-15-16-7-8-16)25(20)30-24(29-22)17-9-10-23(33-2)21(27)13-17/h4-6,9-10,13-14,16H,3,7-8,11-12,15H2,1-2H3,(H,28,32)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/a7.825



GRÜNENTHAL GMBH

US Patent


Assay Description
The test compound or water (control) is mixed with the human recombinant PDE4B1 enzyme (4.8 U) in a buffer consisting of 44.4 mM tris-HCl, 5.28 mM Mg...

US Patent US9688683 (2017)


BindingDB Entry DOI: 10.7270/Q2J38QP9
More data for this
Ligand-Target Pair