BDBM175797 US9688683, 78

SMILES: COc1ccc(cc1F)-c1ncc2c(n1)N(CC21CC1)c1cccc(OC(=O)N(C)C)c1

InChI Key: InChIKey=QLNMMSOXDRRUIN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 175797   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM175797 (US9688683, 78) Show SMILES COc1ccc(cc1F)-c1ncc2c(n1)N(CC21CC1)c1cccc(OC(=O)N(C)C)c1 Show InChI InChI=1S/C24H23FN4O3/c1-28(2)23(30)32-17-6-4-5-16(12-17)29-14-24(9-10-24)18-13-26-21(27-22(18)29)15-7-8-20(31-3)19(25)11-15/h4-8,11-13H,9-10,14H2,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	7.8	25
GRÜNENTHAL GMBH US Patent					Assay Description The test compound or water (control) is mixed with the human recombinant PDE4B1 enzyme (4.8 U) in a buffer consisting of 44.4 mM tris-HCl, 5.28 mM Mg...				US Patent US9688683 (2017) BindingDB Entry DOI: 10.7270/Q2J38QP9
					More data for this Ligand-Target Pair