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SMILES: CCc1nc(nc2n(ccc12)-c1cccc(OC(=O)N(C)C)c1)-c1cccc(c1)S(C)(=O)=O

InChI Key: InChIKey=VGRJIWMNVIHMFU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 175800   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM175800
PNG
(US9688683, 81)
Show SMILES CCc1nc(nc2n(ccc12)-c1cccc(OC(=O)N(C)C)c1)-c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C24H24N4O4S/c1-5-21-20-12-13-28(17-9-7-10-18(15-17)32-24(29)27(2)3)23(20)26-22(25-21)16-8-6-11-19(14-16)33(4,30)31/h6-15H,5H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/a7.825



GRÜNENTHAL GMBH

US Patent


Assay Description
The test compound or water (control) is mixed with the human recombinant PDE4B1 enzyme (4.8 U) in a buffer consisting of 44.4 mM tris-HCl, 5.28 mM Mg...

US Patent US9688683 (2017)


BindingDB Entry DOI: 10.7270/Q2J38QP9
More data for this
Ligand-Target Pair