BDBM175965 US9688684, Compound 162: 8-(1-Benzyl-3-isopropyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine

SMILES: CC(C)c1nn(Cc2ccccc2)cc1C1N(Cc2cccs2)CCn2nnnc12

InChI Key: InChIKey=FTJFDEPQTPZCBY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 175965   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Retinoid-related orphan receptor gamma (RORγ-LBD) (Homo sapiens (Human))	BDBM175965 (US9688684, Compound 162: 8-(1-Benzyl-3-isopropyl-1...) Show SMILES CC(C)c1nn(Cc2ccccc2)cc1C1N(Cc2cccs2)CCn2nnnc12 Show InChI InChI=1S/C22H25N7S/c1-16(2)20-19(15-28(24-20)13-17-7-4-3-5-8-17)21-22-23-25-26-29(22)11-10-27(21)14-18-9-6-12-30-18/h3-9,12,15-16,21H,10-11,13-14H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Patent GmbH US Patent					Assay Description For the assay 12,500 293T cells (DSMZ no ACC 635) per 384 well are seeded in 30 μl inMEM Eagle medium, supplemented with 10% FBS, 2 mM Glutamax,...				US Patent US9688684 (2017) BindingDB Entry DOI: 10.7270/Q2DB7ZZK
					More data for this Ligand-Target Pair
Retinoid-related orphan receptor gamma (RORγ-LBD) (Homo sapiens (Human))	BDBM175965 (US9688684, Compound 162: 8-(1-Benzyl-3-isopropyl-1...) Show SMILES CC(C)c1nn(Cc2ccccc2)cc1C1N(Cc2cccs2)CCn2nnnc12 Show InChI InChI=1S/C22H25N7S/c1-16(2)20-19(15-28(24-20)13-17-7-4-3-5-8-17)21-22-23-25-26-29(22)11-10-27(21)14-18-9-6-12-30-18/h3-9,12,15-16,21H,10-11,13-14H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	6.8	n/a
Merck Patent GmbH US Patent					Assay Description In this assay, a GST-tagged human RORγ ligand binding domain (GST-hRORγ-LBD) interacts with a synthetic biotinylated TRAP220 cofactor pepti...				US Patent US9688684 (2017) BindingDB Entry DOI: 10.7270/Q2DB7ZZK
					More data for this Ligand-Target Pair