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SMILES: COc1cc(OCc2csc(Nc3cc(F)ccc3F)n2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1

InChI Key: InChIKey=NJKPAHMQRWYARR-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 176232   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM176232 (US10047103, 265 | US9688695, 265) Show SMILES COc1cc(OCc2csc(Nc3cc(F)ccc3F)n2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1 Show InChI InChI=1S/C26H19F2N5O3S/c1-14-3-6-25-30-21(11-33(25)32-14)24-10-18-22(8-17(34-2)9-23(18)36-24)35-12-16-13-37-26(29-16)31-20-7-15(27)4-5-19(20)28/h3-11,13H,12H2,1-2H3,(H,29,31)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	48	n/a	n/a	n/a	25
BRISTOL-MYERS SQUIBB COMPANY US Patent					Assay Description Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...				US Patent US9688695 (2017) BindingDB Entry DOI: 10.7270/Q28K777N
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176232 (US10047103, 265 | US9688695, 265) Show SMILES COc1cc(OCc2csc(Nc3cc(F)ccc3F)n2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1 Show InChI InChI=1S/C26H19F2N5O3S/c1-14-3-6-25-30-21(11-33(25)32-14)24-10-18-22(8-17(34-2)9-23(18)36-24)35-12-16-13-37-26(29-16)31-20-7-15(27)4-5-19(20)28/h3-11,13H,12H2,1-2H3,(H,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM176232 (US10047103, 265 | US9688695, 265) Show SMILES COc1cc(OCc2csc(Nc3cc(F)ccc3F)n2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1 Show InChI InChI=1S/C26H19F2N5O3S/c1-14-3-6-25-30-21(11-33(25)32-14)24-10-18-22(8-17(34-2)9-23(18)36-24)35-12-16-13-37-26(29-16)31-20-7-15(27)4-5-19(20)28/h3-11,13H,12H2,1-2H3,(H,29,31)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	48	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM176232 (US10047103, 265 | US9688695, 265) Show SMILES COc1cc(OCc2csc(Nc3cc(F)ccc3F)n2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1 Show InChI InChI=1S/C26H19F2N5O3S/c1-14-3-6-25-30-21(11-33(25)32-14)24-10-18-22(8-17(34-2)9-23(18)36-24)35-12-16-13-37-26(29-16)31-20-7-15(27)4-5-19(20)28/h3-11,13H,12H2,1-2H3,(H,29,31)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>3.00E+3	n/a	n/a	n/a	25
BRISTOL-MYERS SQUIBB COMPANY US Patent					Assay Description Briefly, PRP or washed platelet suspension (100 μl) was pre-incubated for 5 minutes at room temperature with varying concentrations of compounds...				US Patent US9688695 (2017) BindingDB Entry DOI: 10.7270/Q28K777N
					More data for this Ligand-Target Pair