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SMILES: CCCCn1cnc(n1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl

InChI Key: InChIKey=DMCKQHRANNWNMS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 176317   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 1


(Homo sapiens (Human))		BDBM176317
PNG
(US9688696, 32)
Show SMILES CCCCn1cnc(n1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H26Cl2N6O/c1-2-3-11-31-16-26-22(28-31)17-7-9-18(10-8-17)29-12-14-30(15-13-29)23(32)27-21-19(24)5-4-6-20(21)25/h4-10,16H,2-3,11-15H2,1H3,(H,27,32)
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 83n/an/an/an/a7.425



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...

US Patent US9688696 (2017)


BindingDB Entry DOI: 10.7270/Q24X55ZP
More data for this
Ligand-Target Pair