BDBM176771 US9675612, 14 1-(3-Hydroxy-3-methylazetidin-1-yl)-3-[7-(1H-indazol-5-ylamino)[1,3]thiazolo[5,4-d]pyrimidin-2-yl]propan-1-one

SMILES: CC1(O)CN(C1)C(=O)CCc1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1

InChI Key: InChIKey=ZOAUVUPYVLBWMI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 176771   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (T344D) (Homo sapiens (Human))	BDBM176771 (US9675612, 14 1-(3-Hydroxy-3-methylazetidin-1-yl)-...) Show SMILES CC1(O)CN(C1)C(=O)CCc1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1 Show InChI InChI=1S/C19H19N7O2S/c1-19(28)8-26(9-19)15(27)5-4-14-24-16-17(20-10-21-18(16)29-14)23-12-2-3-13-11(6-12)7-22-25-13/h2-3,6-7,10,28H,4-5,8-9H2,1H3,(H,22,25)(H,20,21,23)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	126	n/a	n/a	n/a	n/a	7.5	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9675612 (2017) BindingDB Entry DOI: 10.7270/Q2RN3612
					More data for this Ligand-Target Pair