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SMILES: OC(CNC(=O)c1ccc(cc1)-c1ccccn1)CN1CCc2ccccc2C1

InChI Key: InChIKey=XUYADUJNHAMDAK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 176832   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM176832 (US10307413, Compound 13 | US10391089, Compound 13 ...) Show SMILES OC(CNC(=O)c1ccc(cc1)-c1ccccn1)CN1CCc2ccccc2C1 Show InChI InChI=1S/C24H25N3O2/c28-22(17-27-14-12-18-5-1-2-6-21(18)16-27)15-26-24(29)20-10-8-19(9-11-20)23-7-3-4-13-25-23/h1-11,13,22,28H,12,14-17H2,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US9675614 (2017) BindingDB Entry DOI: 10.7270/Q2MW2F9B
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM176832 (US10307413, Compound 13 | US10391089, Compound 13 ...) Show SMILES OC(CNC(=O)c1ccc(cc1)-c1ccccn1)CN1CCc2ccccc2C1 Show InChI InChI=1S/C24H25N3O2/c28-22(17-27-14-12-18-5-1-2-6-21(18)16-27)15-26-24(29)20-10-8-19(9-11-20)23-7-3-4-13-25-23/h1-11,13,22,28H,12,14-17H2,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US10980794 (2021)
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM176832 (US10307413, Compound 13 | US10391089, Compound 13 ...) Show SMILES OC(CNC(=O)c1ccc(cc1)-c1ccccn1)CN1CCc2ccccc2C1 Show InChI InChI=1S/C24H25N3O2/c28-22(17-27-14-12-18-5-1-2-6-21(18)16-27)15-26-24(29)20-10-8-19(9-11-20)23-7-3-4-13-25-23/h1-11,13,22,28H,12,14-17H2,(H,26,29)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US10391089 (2019) BindingDB Entry DOI: 10.7270/Q2RN3B7D
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM176832 (US10307413, Compound 13 | US10391089, Compound 13 ...) Show SMILES OC(CNC(=O)c1ccc(cc1)-c1ccccn1)CN1CCc2ccccc2C1 Show InChI InChI=1S/C24H25N3O2/c28-22(17-27-14-12-18-5-1-2-6-21(18)16-27)15-26-24(29)20-10-8-19(9-11-20)23-7-3-4-13-25-23/h1-11,13,22,28H,12,14-17H2,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				J Med Chem 52: 3073-83 (2009) BindingDB Entry DOI: 10.7270/Q2ZG6VMT
					More data for this Ligand-Target Pair