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SMILES: CN1CCN(Cc2cccc(c2)C(=O)NCC(O)CN2CCc3ccccc3C2)C(CO)C1

InChI Key: InChIKey=NQWQQRFHOAVRHC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 176997   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM176997 (US10307413, Compound 115 | US10391089, Compound 11...) Show SMILES CN1CCN(Cc2cccc(c2)C(=O)NCC(O)CN2CCc3ccccc3C2)C(CO)C1 Show InChI InChI=1S/C26H36N4O3/c1-28-11-12-30(24(17-28)19-31)15-20-5-4-8-22(13-20)26(33)27-14-25(32)18-29-10-9-21-6-2-3-7-23(21)16-29/h2-8,13,24-25,31-32H,9-12,14-19H2,1H3,(H,27,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US9675614 (2017) BindingDB Entry DOI: 10.7270/Q2MW2F9B
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM176997 (US10307413, Compound 115 | US10391089, Compound 11...) Show SMILES CN1CCN(Cc2cccc(c2)C(=O)NCC(O)CN2CCc3ccccc3C2)C(CO)C1 Show InChI InChI=1S/C26H36N4O3/c1-28-11-12-30(24(17-28)19-31)15-20-5-4-8-22(13-20)26(33)27-14-25(32)18-29-10-9-21-6-2-3-7-23(21)16-29/h2-8,13,24-25,31-32H,9-12,14-19H2,1H3,(H,27,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US10980794 (2021) BindingDB Entry DOI: 10.7270/Q25X2D23
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM176997 (US10307413, Compound 115 | US10391089, Compound 11...) Show SMILES CN1CCN(Cc2cccc(c2)C(=O)NCC(O)CN2CCc3ccccc3C2)C(CO)C1 Show InChI InChI=1S/C26H36N4O3/c1-28-11-12-30(24(17-28)19-31)15-20-5-4-8-22(13-20)26(33)27-14-25(32)18-29-10-9-21-6-2-3-7-23(21)16-29/h2-8,13,24-25,31-32H,9-12,14-19H2,1H3,(H,27,33)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US10391089 (2019) BindingDB Entry DOI: 10.7270/Q2RN3B7D
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM176997 (US10307413, Compound 115 | US10391089, Compound 11...) Show SMILES CN1CCN(Cc2cccc(c2)C(=O)NCC(O)CN2CCc3ccccc3C2)C(CO)C1 Show InChI InChI=1S/C26H36N4O3/c1-28-11-12-30(24(17-28)19-31)15-20-5-4-8-22(13-20)26(33)27-14-25(32)18-29-10-9-21-6-2-3-7-23(21)16-29/h2-8,13,24-25,31-32H,9-12,14-19H2,1H3,(H,27,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				J Med Chem 52: 3073-83 (2009) BindingDB Entry DOI: 10.7270/Q2ZG6VMT
					More data for this Ligand-Target Pair