null

SMILES: CC(=O)c1cnc2ccc(cc2c1N[C@H]1CC[C@H](CN2CCCC(N)C2)CC1)-c1cc(F)c(O)c(Cl)c1

InChI Key: InChIKey=ISXSHIWBHAEAOG-NULPYHFVSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 177452   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Maternal embryonic leucine zipper kinase (Homo sapiens (Human))	BDBM177452 (US9120749, 818) Show SMILES CC(=O)c1cnc2ccc(cc2c1N[C@H]1CC[C@H](CN2CCCC(N)C2)CC1)-c1cc(F)c(O)c(Cl)c1 |r,wU:17.19,wD:14.15,(6.5,-4.41,;5.16,-3.64,;5.16,-2.1,;3.83,-4.41,;3.83,-5.95,;2.5,-6.72,;1.16,-5.95,;-.17,-6.72,;-1.5,-5.95,;-1.5,-4.41,;-.17,-3.64,;1.16,-4.41,;2.5,-3.64,;2.5,-2.1,;1.41,-1.01,;1.81,.48,;.72,1.57,;-.77,1.17,;-1.86,2.26,;-1.46,3.74,;-2.55,4.83,;-2.15,6.32,;-.66,6.72,;.43,5.63,;1.91,6.03,;.03,4.14,;-1.17,-.32,;-.08,-1.41,;-2.84,-3.64,;-2.84,-2.1,;-4.17,-1.33,;-4.17,.21,;-5.5,-2.1,;-6.84,-1.33,;-5.5,-3.64,;-6.84,-4.41,;-4.17,-4.41,)| Show InChI InChI=1S/C29H34ClFN4O2/c1-17(36)24-14-33-27-9-6-19(20-12-25(30)29(37)26(31)13-20)11-23(27)28(24)34-22-7-4-18(5-8-22)15-35-10-2-3-21(32)16-35/h6,9,11-14,18,21-22,37H,2-5,7-8,10,15-16,32H2,1H3,(H,33,34)/t18-,21?,22-	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	7.4	25
ONCOTHERAPY SCIENCE, INC. US Patent					Assay Description MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...				US Patent US9120749 (2015) BindingDB Entry DOI: 10.7270/Q2FX7872
					More data for this Ligand-Target Pair