BDBM17752 2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]phosphoryl}methyl)pentanedioic acid::CHEMBL64901::pentanedioic acid analogue, (RS)-2

SMILES: OC(=O)CCC(CP(O)(=O)Cc1c(F)c(F)c(F)c(F)c1F)C(O)=O

InChI Key: InChIKey=SVAHMQCUSNJPRX-UHFFFAOYSA-N

Data: 4 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 17752   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate Carboxypeptidase II (GCPII) (Homo sapiens (Human))	BDBM17752 (2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]ph...) Show SMILES OC(=O)CCC(CP(O)(=O)Cc1c(F)c(F)c(F)c(F)c1F)C(O)=O Show InChI InChI=1S/C13H12F5O6P/c14-8-6(9(15)11(17)12(18)10(8)16)4-25(23,24)3-5(13(21)22)1-2-7(19)20/h5H,1-4H2,(H,19,20)(H,21,22)(H,23,24)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	7.4	37
Guilford					Assay Description GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...				J Med Chem 48: 2319-24 (2005) Article DOI: 10.1021/jm049258g BindingDB Entry DOI: 10.7270/Q2D50K77
					More data for this Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII) (Homo sapiens (Human))	BDBM17752 (2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]ph...) Show SMILES OC(=O)CCC(CP(O)(=O)Cc1c(F)c(F)c(F)c(F)c1F)C(O)=O Show InChI InChI=1S/C13H12F5O6P/c14-8-6(9(15)11(17)12(18)10(8)16)4-25(23,24)3-5(13(21)22)1-2-7(19)20/h5H,1-4H2,(H,19,20)(H,21,22)(H,23,24)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	7.4	37
MGI Pharma					Assay Description GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...				J Med Chem 49: 2876-85 (2006) Article DOI: 10.1021/jm051019l BindingDB Entry DOI: 10.7270/Q28C9TJD
					More data for this Ligand-Target Pair
Glutamate carboxypeptidase II (Homo sapiens (Human))	BDBM17752 (2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]ph...) Show SMILES OC(=O)CCC(CP(O)(=O)Cc1c(F)c(F)c(F)c(F)c1F)C(O)=O Show InChI InChI=1S/C13H12F5O6P/c14-8-6(9(15)11(17)12(18)10(8)16)4-25(23,24)3-5(13(21)22)1-2-7(19)20/h5H,1-4H2,(H,19,20)(H,21,22)(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	9.5	n/a	n/a	n/a	n/a
Guilford Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibitory concentration required against Glutamate carboxypeptidase II				Bioorg Med Chem Lett 13: 2097-100 (2003) BindingDB Entry DOI: 10.7270/Q2Z60NF2
					More data for this Ligand-Target Pair
Glutamate carboxypeptidase II (Rattus norvegicus)	BDBM17752 (2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]ph...) Show SMILES OC(=O)CCC(CP(O)(=O)Cc1c(F)c(F)c(F)c(F)c1F)C(O)=O Show InChI InChI=1S/C13H12F5O6P/c14-8-6(9(15)11(17)12(18)10(8)16)4-25(23,24)3-5(13(21)22)1-2-7(19)20/h5H,1-4H2,(H,19,20)(H,21,22)(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
Guilford Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibitory concentration against rat brain NAALADase (Folate hydrolase)				J Med Chem 44: 4170-5 (2001) BindingDB Entry DOI: 10.7270/Q2D21WX8
					More data for this Ligand-Target Pair
Glutamate carboxypeptidase II (Homo sapiens (Human))	BDBM17752 (2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]ph...) Show SMILES OC(=O)CCC(CP(O)(=O)Cc1c(F)c(F)c(F)c(F)c1F)C(O)=O Show InChI InChI=1S/C13H12F5O6P/c14-8-6(9(15)11(17)12(18)10(8)16)4-25(23,24)3-5(13(21)22)1-2-7(19)20/h5H,1-4H2,(H,19,20)(H,21,22)(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
Guilford Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of Glutamate carboxypeptidase II				Bioorg Med Chem Lett 13: 2097-100 (2003) BindingDB Entry DOI: 10.7270/Q2Z60NF2
					More data for this Ligand-Target Pair