BDBM177777 US10000475, Compound 6::US9120786, 6

SMILES: NC(=O)c1nc(N[C@H]2CCNC2=O)nc(n1)-c1ccc(Oc2ccc(cn2)C(F)(F)F)cc1

InChI Key: InChIKey=KEVTUCZWDUDRRY-ZDUSSCGKSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 177777   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM177777 (US10000475, Compound 6 | US9120786, 6) Show SMILES NC(=O)c1nc(N[C@H]2CCNC2=O)nc(n1)-c1ccc(Oc2ccc(cn2)C(F)(F)F)cc1 |r| Show InChI InChI=1S/C20H16F3N7O3/c21-20(22,23)11-3-6-14(26-9-11)33-12-4-1-10(2-5-12)16-28-17(15(24)31)30-19(29-16)27-13-7-8-25-18(13)32/h1-6,9,13H,7-8H2,(H2,24,31)(H,25,32)(H,27,28,29,30)/t13-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universite degli Studi di Firenze					Assay Description The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...				Bioorg Med Chem 17: 4503-9 (2009) BindingDB Entry DOI: 10.7270/Q20004F3
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM177777 (US10000475, Compound 6 | US9120786, 6) Show SMILES NC(=O)c1nc(N[C@H]2CCNC2=O)nc(n1)-c1ccc(Oc2ccc(cn2)C(F)(F)F)cc1 |r| Show InChI InChI=1S/C20H16F3N7O3/c21-20(22,23)11-3-6-14(26-9-11)33-12-4-1-10(2-5-12)16-28-17(15(24)31)30-19(29-16)27-13-7-8-25-18(13)32/h1-6,9,13H,7-8H2,(H2,24,31)(H,25,32)(H,27,28,29,30)/t13-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	37
Purdue Pharma, L.P. US Patent					Assay Description FLIPRTETRA Sodium Dye Assay with KCl: Cells were prepared by plating the recombinant HEK293 cells or other host cells expressing either recombinant o...				US Patent US9120786 (2015) BindingDB Entry DOI: 10.7270/Q25D8QKN
					More data for this Ligand-Target Pair