BDBM177814 US9120791, Example 32::US9603854, 32

SMILES: Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2cc3OCCCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1

InChI Key: InChIKey=ACIACBPEMFMEKC-QNGWXLTQSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 177814   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177814 (US9120791, Example 32 | US9603854, 32) Show SMILES Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2cc3OCCCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C48H49N5O6/c1-49-18-16-33-26-36(12-15-42(33)49)53(35-10-13-38(54)14-11-35)48(56)41-27-44(51-17-5-4-9-43(41)51)39-28-45-46(59-22-6-21-58-45)29-40(39)47(55)52-30-34-8-3-2-7-32(34)25-37(52)31-50-19-23-57-24-20-50/h2-3,7-8,10-16,18,26-29,37,54H,4-6,9,17,19-25,30-31H2,1H3/t37-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177814 (US9120791, Example 32 | US9603854, 32) Show SMILES Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2cc3OCCCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C48H49N5O6/c1-49-18-16-33-26-36(12-15-42(33)49)53(35-10-13-38(54)14-11-35)48(56)41-27-44(51-17-5-4-9-43(41)51)39-28-45-46(59-22-6-21-58-45)29-40(39)47(55)52-30-34-8-3-2-7-32(34)25-37(52)31-50-19-23-57-24-20-50/h2-3,7-8,10-16,18,26-29,37,54H,4-6,9,17,19-25,30-31H2,1H3/t37-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair