BDBM177828 US9120791, Example 47::US9603854, 47

SMILES: Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2cc(ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)C(F)(F)F)n2CCCCc12)c1ccc(O)cc1

InChI Key: InChIKey=YOOZPVGVNNBNPO-BHVANESWSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 177828   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177828 (US9120791, Example 47 | US9603854, 47) Show SMILES Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2cc(ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)C(F)(F)F)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C46H44F3N5O4/c1-50-19-17-31-25-35(12-16-41(31)50)54(34-10-13-37(55)14-11-34)45(57)40-27-43(52-18-5-4-8-42(40)52)39-26-33(46(47,48)49)9-15-38(39)44(56)53-28-32-7-3-2-6-30(32)24-36(53)29-51-20-22-58-23-21-51/h2-3,6-7,9-17,19,25-27,36,55H,4-5,8,18,20-24,28-29H2,1H3/t36-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177828 (US9120791, Example 47 | US9603854, 47) Show SMILES Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2cc(ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)C(F)(F)F)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C46H44F3N5O4/c1-50-19-17-31-25-35(12-16-41(31)50)54(34-10-13-37(55)14-11-34)45(57)40-27-43(52-18-5-4-8-42(40)52)39-26-33(46(47,48)49)9-15-38(39)44(56)53-28-32-7-3-2-6-30(32)24-36(53)29-51-20-22-58-23-21-51/h2-3,6-7,9-17,19,25-27,36,55H,4-5,8,18,20-24,28-29H2,1H3/t36-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	58	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair