null

SMILES: CSc1ccc(cc1C(F)(F)F)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1

InChI Key: InChIKey=AXLXBLULIRCIQK-XIFFEERXSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 177835   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177835 (US9120791, Example 54 | US9603854, 54) Show SMILES CSc1ccc(cc1C(F)(F)F)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C44H42ClF3N4O4S/c1-57-41-16-12-32(24-38(41)44(46,47)48)52(31-10-13-34(53)14-11-31)43(55)37-25-40(50-17-5-4-8-39(37)50)36-23-30(45)9-15-35(36)42(54)51-26-29-7-3-2-6-28(29)22-33(51)27-49-18-20-56-21-19-49/h2-3,6-7,9-16,23-25,33,53H,4-5,8,17-22,26-27H2,1H3/t33-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177835 (US9120791, Example 54 | US9603854, 54) Show SMILES CSc1ccc(cc1C(F)(F)F)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C44H42ClF3N4O4S/c1-57-41-16-12-32(24-38(41)44(46,47)48)52(31-10-13-34(53)14-11-31)43(55)37-25-40(50-17-5-4-8-39(37)50)36-23-30(45)9-15-35(36)42(54)51-26-29-7-3-2-6-28(29)22-33(51)27-49-18-20-56-21-19-49/h2-3,6-7,9-16,23-25,33,53H,4-5,8,17-22,26-27H2,1H3/t33-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	180	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair