null

SMILES: Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2ccccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2ccccc12)c1ccc(O)cc1

InChI Key: InChIKey=FWSUFQGXQZUGSY-BHVANESWSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 177837   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177837 (US9120791, Example 56 | US9603854, 56) Show SMILES Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2ccccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2ccccc12)c1ccc(O)cc1 Show InChI InChI=1S/C45H41N5O4/c1-46-21-19-32-27-35(15-18-41(32)46)50(34-13-16-37(51)17-14-34)45(53)40-28-43(48-20-7-6-12-42(40)48)38-10-4-5-11-39(38)44(52)49-29-33-9-3-2-8-31(33)26-36(49)30-47-22-24-54-25-23-47/h2-21,27-28,36,51H,22-26,29-30H2,1H3/t36-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177837 (US9120791, Example 56 | US9603854, 56) Show SMILES Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2ccccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2ccccc12)c1ccc(O)cc1 Show InChI InChI=1S/C45H41N5O4/c1-46-21-19-32-27-35(15-18-41(32)46)50(34-13-16-37(51)17-14-34)45(53)40-28-43(48-20-7-6-12-42(40)48)38-10-4-5-11-39(38)44(52)49-29-33-9-3-2-8-31(33)26-36(49)30-47-22-24-54-25-23-47/h2-21,27-28,36,51H,22-26,29-30H2,1H3/t36-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair