BDBM177858 US9120791, Example 80::US9603854, 80

SMILES: Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(O)cc1

InChI Key: InChIKey=FRZQDMRZSLORSU-UMSFTDKQSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 177858   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177858 (US9120791, Example 80 | US9603854, 80) Show SMILES Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(O)cc1 Show InChI InChI=1S/C45H43N5O7/c1-46-13-12-30-21-33(8-11-39(30)46)50(32-6-9-35(51)10-7-32)45(53)38-22-40(48-16-19-55-27-41(38)48)36-23-42-43(57-28-56-42)24-37(36)44(52)49-25-31-5-3-2-4-29(31)20-34(49)26-47-14-17-54-18-15-47/h2-13,21-24,34,51H,14-20,25-28H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177858 (US9120791, Example 80 | US9603854, 80) Show SMILES Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(O)cc1 Show InChI InChI=1S/C45H43N5O7/c1-46-13-12-30-21-33(8-11-39(30)46)50(32-6-9-35(51)10-7-32)45(53)38-22-40(48-16-19-55-27-41(38)48)36-23-42-43(57-28-56-42)24-37(36)44(52)49-25-31-5-3-2-4-29(31)20-34(49)26-47-14-17-54-18-15-47/h2-13,21-24,34,51H,14-20,25-28H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair