null
SMILES: CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-c2cc(C(=O)N(c3ccc(O)cc3)c3ccc4n(C)ccc4c3)c3CCCCn23)CC1=O
InChI Key: InChIKey=IQWJDSLRDOMRAB-BHVANESWSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Apoptosis regulator Bcl-2 (Homo sapiens (Human)) | BDBM177879 (US9120791, Example 107 | US9603854, 107) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent | Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is... | US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apoptosis regulator Bcl-2 (Mus musculus (Mouse)) | BDBM177879 (US9120791, Example 107 | US9603854, 107) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.4 | n/a |
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent | Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is... | US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC | |||||||||||
More data for this Ligand-Target Pair |