BDBM177894 US9120791, Example 124::US9603854, 124

SMILES: COc1cccc(c1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1

InChI Key: InChIKey=HPEVZPKWISDMNP-UMSFTDKQSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 177894   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177894 (US9120791, Example 124 | US9603854, 124) Show SMILES COc1cccc(c1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C43H43ClN4O5/c1-52-36-10-6-9-33(25-36)48(32-13-15-35(49)16-14-32)43(51)39-26-41(46-18-5-4-11-40(39)46)38-24-31(44)12-17-37(38)42(50)47-27-30-8-3-2-7-29(30)23-34(47)28-45-19-21-53-22-20-45/h2-3,6-10,12-17,24-26,34,49H,4-5,11,18-23,27-28H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177894 (US9120791, Example 124 | US9603854, 124) Show SMILES COc1cccc(c1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C43H43ClN4O5/c1-52-36-10-6-9-33(25-36)48(32-13-15-35(49)16-14-32)43(51)39-26-41(46-18-5-4-11-40(39)46)38-24-31(44)12-17-37(38)42(50)47-27-30-8-3-2-7-29(30)23-34(47)28-45-19-21-53-22-20-45/h2-3,6-10,12-17,24-26,34,49H,4-5,11,18-23,27-28H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair