BDBM177897 US9120791, Example 127::US9603854, 127

SMILES: Oc1ccc(cc1)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(CC(F)(F)F)CC2)n2CCCCc12)c1ccccc1

InChI Key: InChIKey=GGDYAYQRFBUOEF-UMSFTDKQSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 177897   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177897 (US9120791, Example 127 | US9603854, 127) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(CC(F)(F)F)CC2)n2CCCCc12)c1ccccc1 Show InChI InChI=1S/C45H44F3N5O5/c46-45(47,48)28-50-20-18-49(19-21-50)27-34-22-30-8-4-5-9-31(30)26-52(34)43(55)37-25-42-41(57-29-58-42)24-36(37)40-23-38(39-12-6-7-17-51(39)40)44(56)53(32-10-2-1-3-11-32)33-13-15-35(54)16-14-33/h1-5,8-11,13-16,23-25,34,54H,6-7,12,17-22,26-29H2/t34-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177897 (US9120791, Example 127 | US9603854, 127) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(CC(F)(F)F)CC2)n2CCCCc12)c1ccccc1 Show InChI InChI=1S/C45H44F3N5O5/c46-45(47,48)28-50-20-18-49(19-21-50)27-34-22-30-8-4-5-9-31(30)26-52(34)43(55)37-25-42-41(57-29-58-42)24-36(37)40-23-38(39-12-6-7-17-51(39)40)44(56)53(32-10-2-1-3-11-32)33-13-15-35(54)16-14-33/h1-5,8-11,13-16,23-25,34,54H,6-7,12,17-22,26-29H2/t34-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair