BDBM17805 N-(6-{[6-({[2-fluoro-5-(trifluoromethyl)phenyl]carbamoyl}amino)pyridin-3-yl]oxy}-1H-1,3-benzodiazol-2-yl)acetamide::benzimidazole-urea, 33

SMILES: CC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)nc3)cc2[nH]1

InChI Key: InChIKey=BDUFSIJFMWAXAX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17805   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM17805 (N-(6-{[6-({[2-fluoro-5-(trifluoromethyl)phenyl]car...) Show SMILES CC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)nc3)cc2[nH]1 Show InChI InChI=1S/C22H16F4N6O3/c1-11(33)28-20-29-16-6-3-13(9-18(16)30-20)35-14-4-7-19(27-10-14)32-21(34)31-17-8-12(22(24,25)26)2-5-15(17)23/h2-10H,1H3,(H2,27,31,32,34)(H2,28,29,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...				J Med Chem 50: 4453-70 (2007) Article DOI: 10.1021/jm0611051 BindingDB Entry DOI: 10.7270/Q20V8B29
					More data for this Ligand-Target Pair