BDBM178337 US9120812, 122

SMILES: CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccn(C)n4)cc3)c2C1=O)N1CC2CCC(C1)O2

InChI Key: InChIKey=XNQKOQIAMIRTRL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 178337   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PI3-kinase class I (Homo sapiens (Human))	BDBM178337 (US9120812, 122) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccn(C)n4)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:32:35.36:39| Show InChI InChI=1S/C28H34N8O4/c1-5-35-16-28(2,3)40-24-22(25(35)37)23(31-26(32-24)36-14-19-10-11-20(15-36)39-19)17-6-8-18(9-7-17)29-27(38)30-21-12-13-34(4)33-21/h6-9,12-13,19-20H,5,10-11,14-16H2,1-4H3,(H2,29,30,33,38)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178337 (US9120812, 122) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccn(C)n4)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:32:35.36:39| Show InChI InChI=1S/C28H34N8O4/c1-5-35-16-28(2,3)40-24-22(25(35)37)23(31-26(32-24)36-14-19-10-11-20(15-36)39-19)17-6-8-18(9-7-17)29-27(38)30-21-12-13-34(4)33-21/h6-9,12-13,19-20H,5,10-11,14-16H2,1-4H3,(H2,29,30,33,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair