BDBM17851 3-[(E)-(2-methylpropylidene)amino]-N-(1,3-thiazol-2-yl)pyridine-2-carboxamide::pyridine-2-carboxylic acid inhibitor, 4

SMILES: CC(C)C=Nc1cccnc1C(=O)Nc1nccs1

InChI Key: InChIKey=FSYKBCHJLUIEBF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 17851   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17851 (3-[(E)-(2-methylpropylidene)amino]-N-(1,3-thiazol-...) Show SMILES CC(C)C=Nc1cccnc1C(=O)Nc1nccs1 |w:4.4| Show InChI InChI=1S/C13H14N4OS/c1-9(2)8-16-10-4-3-5-14-11(10)12(18)17-13-15-6-7-19-13/h3-9H,1-2H3,(H,15,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	7.5	22
Johns Hopkins University					Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...				Proc Natl Acad Sci U S A 103: 18148-53 (2006) Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK
					More data for this Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1) (Homo sapiens (Human))	BDBM17851 (3-[(E)-(2-methylpropylidene)amino]-N-(1,3-thiazol-...) Show SMILES CC(C)C=Nc1cccnc1C(=O)Nc1nccs1 |w:4.4| Show InChI InChI=1S/C13H14N4OS/c1-9(2)8-16-10-4-3-5-14-11(10)12(18)17-13-15-6-7-19-13/h3-9H,1-2H3,(H,15,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	7.5	22
Johns Hopkins University					Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...				Proc Natl Acad Sci U S A 103: 18148-53 (2006) Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK
					More data for this Ligand-Target Pair