BDBM179262 US9126948, 2

SMILES: COc1c(cc(Cl)c(C)c1-c1cncc(c1)C#N)C(C)Nc1ncnc(N)c1C#N

InChI Key: InChIKey=SVTHXLYAWGXNEC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 179262   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM179262 (US9126948, 2) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C#N)C(C)Nc1ncnc(N)c1C#N Show InChI InChI=1S/C21H18ClN7O/c1-11-17(22)5-15(12(2)29-21-16(7-24)20(25)27-10-28-21)19(30-3)18(11)14-4-13(6-23)8-26-9-14/h4-5,8-10,12H,1-3H3,(H3,25,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<20	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...				US Patent US9126948 (2015) BindingDB Entry DOI: 10.7270/Q2P849NB
					More data for this Ligand-Target Pair